With a rapidly aging population, there has been great interest in using cognitive
training to enhance cognitive function in older adults and age-related diseases. Studies
evaluating cognitive enhancing interventions demonstrate mixed findings on efficacy.
Effect sizes are heterogeneous across studies and there is inconsistent evidence of
transfer to improvements in everyday cognitive tasks. To develop more effective treatments,
clinical researchers have increasingly turned to interventions that combine approaches
(e.g., computerized cognitive training, exercise, neuromodulation) and that attempt
to target circuit-specific mechanisms of cognitive dysfunction.
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References
- Strategies to promote cognitive health in aging: recent evidence and innovations.Curr Psychiatry Rep. 2022; 24: 441-450https://doi.org/10.1007/s11920-022-01348-x
- Combined cognitive training and vortioxetine mitigates age-related declines in functional brain network integrity.Am J Geriatr Psychiatry. 2023; https://doi.org/10.1016/j.jagp.2023.01.004
- Vortioxetine, a novel antidepressant with multimodal activity: review of preclinical and clinical data.Pharmacol Ther. 2015; 145: 43-57https://doi.org/10.1016/j.pharmthera.2014.07.001
- Vortioxetine for Cognitive enhancement in major depression: from animal models to clinical research.Front Psychiatry. 2019; 10: 771https://doi.org/10.3389/fpsyt.2019.00771
- A digital intervention targeting cognitive control network dysfunction in middle age and older adults with major depression.Transl Psychiatry. 2021; 11: 269https://doi.org/10.1038/s41398-021-01386-8
- Cognitive training reorganizes network modularity in traumatic brain injury.Neurorehabil Neural Repair. 2020; 34: 26-38https://doi.org/10.1177/1545968319868710
- Modular brain network organization predicts response to cognitive training in older adults.PLoS ONE. 2016; 11: 1-17https://doi.org/10.1371/journal.pone.0169015
Article info
Publication history
Published online: February 06, 2023
Accepted:
January 30,
2023
Received:
January 28,
2023
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.
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- Combined Cognitive Training and Vortioxetine Mitigates Age-Related Declines in Functional Brain Network IntegrityThe American Journal of Geriatric Psychiatry
- PreviewAge-related cognitive decline—normative progressive reduction in cognitive abilities with aging—affects a broad range of fluid cognition domains including memory, executive functioning, and information processing speed.1 It is a heterogeneous phenomenon, likely reflecting multiple etiologies including Alzheimer's and cerebrovascular diseases, as well as individual differences in neurocognitive resilience.2,3 Despite this heterogeneity, age-related cognitive decline is potentially treatable. One putative intervention is cognitive training.
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