Augmentation of Cognitive Training With Vortioxetine Opens New Avenues for Targeting Age-Related Changes in Brain Connectivity

  • Abhishek Jaywant
    Send correspondence and reprint requests to Abhishek Jaywant, P.hD., Department of Psychiatry, Weill Cornell Medicine, 525 E 68th Street, Baker F-1232, New York, NY 10065.
    Department of Psychiatry, Weill Cornell Medicine, New York, NY
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Published:February 06, 2023DOI:
      With a rapidly aging population, there has been great interest in using cognitive training to enhance cognitive function in older adults and age-related diseases. Studies evaluating cognitive enhancing interventions demonstrate mixed findings on efficacy. Effect sizes are heterogeneous across studies and there is inconsistent evidence of transfer to improvements in everyday cognitive tasks. To develop more effective treatments, clinical researchers have increasingly turned to interventions that combine approaches (e.g., computerized cognitive training, exercise, neuromodulation) and that attempt to target circuit-specific mechanisms of cognitive dysfunction.
      • Oberlin LE
      • Jaywant A
      • Wolff A
      • et al.
      Strategies to promote cognitive health in aging: recent evidence and innovations.
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      Linked Article

      • Combined Cognitive Training and Vortioxetine Mitigates Age-Related Declines in Functional Brain Network Integrity
        The American Journal of Geriatric Psychiatry
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          Age-related cognitive decline—normative progressive reduction in cognitive abilities with aging—affects a broad range of fluid cognition domains including memory, executive functioning, and information processing speed.1 It is a heterogeneous phenomenon, likely reflecting multiple etiologies including Alzheimer's and cerebrovascular diseases, as well as individual differences in neurocognitive resilience.2,3 Despite this heterogeneity, age-related cognitive decline is potentially treatable. One putative intervention is cognitive training.
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