Examining Individual Differences in the Within-Person Process of Perceived Stress and Cognitive Functioning to Advance Precision Health: Commentary on “Sex Differences in the Relationship between Perceived Stress and Cognitive Trajectories” by Paolillo et al.

Published:January 28, 2023DOI:
      The Paolillo et al.
      • Paolillo EW
      • You M
      • Gontrum E
      • et al.
      Sex differences in the relationship between perceived stress and cognitive trajectories.
      paper added new findings to the evidence on the longitudinal relationship between sex, perceived stress, inflammation, and cognition among a sample of community-dwelling older adults. In their paper, the authors found a significant interaction between mean perceived stress, sex, and time on executive function (but not in memory or processing speed), such that higher mean perceived stress scores were associated with steeper declines in executive functioning over time in men but not in women. In a subset of the sample who had at inflammatory biomarker data at 2 or more timepoints, there was a significant interaction such that higher mean perceived stress scores were associated with greater increases in IL-6 over time in men but not in women, suggesting resilience to executive dysfunction as a consequence of stress induced inflammation.
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      • Sex Differences in the Relationship between Perceived Stress and Cognitive Trajectories
        The American Journal of Geriatric Psychiatry
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          Chronic stress adversely affects cognition, in part due to stress-induced inflammation. Rodent models suggest females are more resilient against stress-related cognitive dysfunction than males; however, few studies have examined this in humans. We examined sex differences in the relationship between perceived stress, cognitive functioning, and peripheral inflammation over time among cognitively normal older adults.
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