The Paolillo et al.
1paper added new findings to the evidence on the longitudinal relationship between sex, perceived stress, inflammation, and cognition among a sample of community-dwelling older adults. In their paper, the authors found a significant interaction between mean perceived stress, sex, and time on executive function (but not in memory or processing speed), such that higher mean perceived stress scores were associated with steeper declines in executive functioning over time in men but not in women. In a subset of the sample who had at inflammatory biomarker data at 2 or more timepoints, there was a significant interaction such that higher mean perceived stress scores were associated with greater increases in IL-6 over time in men but not in women, suggesting resilience to executive dysfunction as a consequence of stress induced inflammation.
- Paolillo EW
- You M
- Gontrum E
- et al.
Sex differences in the relationship between perceived stress and cognitive trajectories.
Am J Geriatr Psychiatry. 2023; (In press)https://doi.org/10.1016/j.jagp.2022.11.009
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- Sex differences in the relationship between perceived stress and cognitive trajectories.Am J Geriatr Psychiatry. 2023; (In press)https://doi.org/10.1016/j.jagp.2022.11.009
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Published online: January 28, 2023
Accepted: January 22, 2023
Received: January 19, 2023
Publication stageIn Press Journal Pre-Proof
© 2023 Published by Elsevier Inc. on behalf of American Association for Geriatric Psychiatry.
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- Sex Differences in the Relationship between Perceived Stress and Cognitive TrajectoriesThe American Journal of Geriatric Psychiatry
- PreviewChronic stress adversely affects cognition, in part due to stress-induced inflammation. Rodent models suggest females are more resilient against stress-related cognitive dysfunction than males; however, few studies have examined this in humans. We examined sex differences in the relationship between perceived stress, cognitive functioning, and peripheral inflammation over time among cognitively normal older adults.