ABSTRACT
As the most reported symptom in old age, fatigue is understudied in terms of both
mechanisms and measures. Population heterogeneity and methodological inconsistency
makes understanding the relationship between fatigue and brain aging challenging.
The present article comprehensively reviews existing conceptual and operational frameworks
of fatigue, as well as mechanistic heterogeneities of fatigue that exist in the aging
literature. Then, I propose a Multi-Dimensional Model of fatigue to provide theoretical
cohesion to the study of fatigue in old age, along with a “fatigue circuit” addressing
brain profiles across dimensions of fatigue. The potential relationships between fatigue
dimensions, the fatigue circuit, and brain aging are discussed to inform the direction
of future research.
Keywords
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Article Info
Publication History
Published online: November 04, 2022
Accepted:
October 31,
2022
Received in revised form:
October 13,
2022
Received:
June 15,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.
