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Psychosocial Determinants of Biological Aging in Older Adults: What is Next?

  • Breno S. Diniz
    Correspondence
    Send correspondence and reprint requests to Breno S. Diniz, UConn Center on Aging & Department of Psychiatry, School of Medicine, University of Connecticut Health Science Center, 263 Farmington Ave., Farmington, CT 06030.
    Affiliations
    UConn Center on Aging & Department of Psychiatry, School of Medicine, University of Connecticut Health Science Center, Farmington, CT
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Published:September 23, 2022DOI:https://doi.org/10.1016/j.jagp.2022.09.012
      Aging is a highly heterogenous process and a major risk factor for a myriad of adverse health outcomes. A major quest in biomedical research is the search for metrics (i.e., biological aging measures) that can provide a more accurate information about our aging process, reducing the sample heterogeneity, predicting adverse health outcomes, and informing biological mechanisms of aging.
      • Rutledge J
      • Oh H
      • Wyss-Coray T
      Measuring biological age using omics data.
      Among many biological aging measures, the epigenetic clocks based on specific patterns of DNA methylation have become popular measures of biological aging.
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      Linked Article

      • Psychosocial Factors Associated With Accelerated GrimAge in Male U.S. Military Veterans
        The American Journal of Geriatric Psychiatry
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          An estimated 46% of veterans are aged 65 and older, and this percentage is projected to increase to 56% in 2024.1 Increasing chronological age magnifies risk for mental and physical health comorbidities relative to younger veterans.2 However, there are substantial individual differences in risk for these morbidities that are often inadequately accounted for by chronological age. In efforts to better understand processes that underlie these differences, there is increasing interest in studying biomarkers of aging.
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