Aging is a highly heterogenous process and a major risk factor for a myriad of adverse
health outcomes. A major quest in biomedical research is the search for metrics (i.e.,
biological aging measures) that can provide a more accurate information about our
aging process, reducing the sample heterogeneity, predicting adverse health outcomes,
and informing biological mechanisms of aging.
1
Among many biological aging measures, the epigenetic clocks based on specific patterns
of DNA methylation have become popular measures of biological aging.- Rutledge J
- Oh H
- Wyss-Coray T
Measuring biological age using omics data.
Nat Rev Genet. 2022; (In press)https://doi.org/10.1038/s41576-022-00511-7
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References
- Measuring biological age using omics data.Nat Rev Genet. 2022; (In press)https://doi.org/10.1038/s41576-022-00511-7
- DNA methylation age of human tissues and cell types.Genome Biol. 2013; 14: R115
- Genome-wide methylation profiles reveal quantitative views of human aging rates.Mol Cell. 2013; 49: 359-367
- DNA methylation GrimAge strongly predicts lifespan and healthspan.Aging (Albany NY). 2019; 11: 303-327
- DunedinPACE, a DNA methylation biomarker of the pace of aging.Elife. 2022; 11: e73420
- Brain age and other bodily 'ages': implications for neuropsychiatry.Mol Psychiatry. 2019; 24: 266-281
- Psychosocial factors associated with accelerated GrimAge in male U.S. military veterans.Am J Geriatr Psychiatry. 2022; (S1064-7481(22)00503-6)https://doi.org/10.1016/j.jagp.2022.09.002
- Time for united action on depression: a lancet-world psychiatric association commission.Lancet. 2022; 399: 957-1022
Article Info
Publication History
Published online: September 23, 2022
Accepted:
September 21,
2022
Received:
September 21,
2022
Publication stage
In Press Journal Pre-ProofFootnotes
Breno S. Diniz is the sole contributor of this editorial.
Identification
Copyright
© 2022 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.
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- Psychosocial Factors Associated With Accelerated GrimAge in Male U.S. Military VeteransThe American Journal of Geriatric Psychiatry
- PreviewAn estimated 46% of veterans are aged 65 and older, and this percentage is projected to increase to 56% in 2024.1 Increasing chronological age magnifies risk for mental and physical health comorbidities relative to younger veterans.2 However, there are substantial individual differences in risk for these morbidities that are often inadequately accounted for by chronological age. In efforts to better understand processes that underlie these differences, there is increasing interest in studying biomarkers of aging.
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