Strokes increase the risk of cognitive impairment and dementia, and the risk of poststroke
cognitive decline does not suside with time.
1
Selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine, display neuroprotective,
and neuroregenerative properties in animal models of brain ischemia,
2
raising hope that their use could lessen the detrimental effects of stroke on cognition.To read this article in full you will need to make a payment
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References
- Association of ischemic stroke incidence, severity, and recurrence with dementia in the Atherosclerosis Risk in Communities Cohort Study.JAMA Neurol. 2022; 79: 271-280
- Chronic fluoxetine treatment improves ischemia-induced spatial cognitive deficits through increasing hippocampal neurogenesis after stroke.J Neurosci Res. 2009; 87: 112-122
- Safety and efficacy of fluoxetine on functional outcome after acute stroke (AFFINITY): a randomised, double-blind, placebo-controlled trial.Lancet Neurol. 2020; 19: 651-660
- Utility of TICS-M for the assessment of cognitive function in older adults.Int J Geriatr Psychiatry. 2003; 18: 318-324
- Depression outcomes among patients treated with fluoxetine for stroke recovery: the AFFINITY randomized clinical trial.JAMA Neurol. 2021; 78: 1072-1079
Article info
Publication history
Published online: August 19, 2022
Accepted:
August 17,
2022
Received in revised form:
August 17,
2022
Received:
August 9,
2022
Identification
Copyright
© 2022 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.
