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Five-Year Longitudinal Evidence Supports the Safety and Efficacy of Electroconvulsive Therapy for Older Adults With Major Depressive Disorder

      Major depressive disorder (MDD) in older adults is a severe neuropsychiatric illness that results in significant disability, morbidity, and mortality.
      • Jeuring HW
      • Stek ML
      • Huisman M
      • et al.
      A six-year prospective study of the prognosis and predictors in patients with late-life depression.
      While antidepressant treatment strategies have evolved considerably in recent years, many maybe ineffective and unable to alleviate depressive symptoms.
      • Lenze EJ
      • Sheffrin M
      • Driscoll HC
      • et al.
      Incomplete response in late-life depression: getting to remission.
      For such treatment-resistant and difficult to treat depression, the main and most effective treatment option is electroconvulsive therapy (ECT). Indeed, for older adults with MDD and difficult to treat depression, converging evidence collected over decades, including the relatively recently completed National Institute of Mental Health supported Prolonging Remission in Depressed Elderly (PRIDE) Study, substantiates the safety and efficacy of ECT.
      • Kellner CH
      • Husain MM
      • Knapp RG
      • et al.
      Right unilateral ultrabrief pulse electroconvulsive therapy (ECT) in geriatric depression: phase 1 of the PRIDE Study.
      • Kellner CH
      • Husain MM
      • Knapp RG
      • et al.
      A novel strategy for continuation electroconvulsive therapy in geriatric depression: phase 2 of the PRIDE Study.
      • Lisanby SH
      • McClintock SM
      • Alexopoulos G
      • et al.
      Neurocognitive effects of combined electroconvulsive therapy (ECT) and venlafaxine in geriatric depression: Phase 1 of the PRIDE Study.
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      References

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