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Editorial| Volume 30, ISSUE 2, P195-196, February 2022

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Less Anxiety, Better Learning, More Studies

  • Tarek K. Rajji
    Correspondence
    Send correspondence and reprint requests to Tarek K. Rajji, MD, FRCPC, Centre for Addiction and Mental Health, 80 Workman Way Room 6312, Toronto, ON Canada M6J1H4; Tel: 416 535 8501 ext. 33661, Fax: 416 583 1272.
    Affiliations
    Department of Psychiatry & Toronto Dementia Research Alliance, University of Toronto, Canada Research Chair in Neurostimulation for Cognitive Disorders, Adult Neurodevelopment and Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, ON M6J 1H4
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      Subjective cognitive decline (SCD) is an early stage of cognitive impairment that is mainly manifest as a subjective experience of cognitive worsening.
      • Jessen F
      • Amariglio RE
      • van Boxtel M
      • et al.
      A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease.
      SCD is, for some individuals, an early clinical stage of Alzheimer's disease and related dementias, preceding mild cognitive impairment. Thus, discovering therapeutic interventions that can halt or reverse cognitive decline during early clinical stages of a neurodegenerative disease, including SCD, are highly needed to reduce the burden of Alzheimer's disease and related dementias on the individual and society.
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      References

        • Jessen F
        • Amariglio RE
        • van Boxtel M
        • et al.
        A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease.
        Alzheimers Dement. 2014; 10: 844-852
        • Smart CM
        • Karr JE
        • Areshenkoff CN
        • et al.
        Non-pharmacologic interventions for older adults with subjective cognitive decline: systematic review, meta-analysis, and preliminary recommendations.
        Neuropsychol Rev. 2017; 27: 245-257
        • Yin S
        • Zhu X
        • Li R
        • et al.
        Alleviated anxiety boosts memory training gain in older adults with subjective memory complaints: a randomized controlled trial.
        Am J Geriatr Psychiatry. 2022; 30: 184-194
        • Rajji TK
        • Bowie CR
        • Herrmann N
        • et al.
        Design and rationale of the PACt-MD randomized clinical trial: prevention of Alzheimer's dementia with cognitive remediation plus transcranial direct current stimulation in mild cognitive impairment and depression.
        J Alzheimers Dis. 2020; 76: 733-751