Over the past several decades, there has been increasing awareness of and focus on
the nonmotor aspects of Parkinson's disease (PD). These include disordered autonomic
function, cognitive impairment, and neuropsychiatric features including depression,
anxiety, and psychosis. Neuropsychiatric symptoms are common, contribute to PD-related
disability, and negatively impact health-related quality of life. In spite of the
increasing awareness, these symptoms may still go unrecognized and under-treated due
to an inappropriate singular focus on motor symptoms. Compounding this, the current
evidence base is insufficient to guide appropriate treatment of psychiatric symptoms
in PD. Treatment approaches often reflect those used in the general population, which
may not be appropriate given suspected differences in mechanisms. A better understanding
of the underlying pathophysiology may inform approaches toward treatment.
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Article info
Publication history
Published online: January 18, 2021
Accepted:
January 12,
2021
Received:
January 11,
2021
Identification
Copyright
© 2021 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.
