There is a growing consensus on the influence neural networks of the mesocorticolimbic brain system on neuropsychiatric disorders. Neural networks consist of clusters of connected circuits identified with functional magnetic resonance imaging of the brain. Multiple networks including the default mode network (DMN), salience network, and executive function also described as the cognitive control network are implicated in both the presentation of depressive symptoms but also as moderators of treatment response. Aberrations in the functional connectivity patterns both within and between these networks are implicated in mood disorders and suicidality.
1The DMN sometimes said to be the daydreaming or self-reflection network, becomes overly engaged with internally preoccupied thought during depressive episodes. The executive function network which normally is involved in planning, initiating, stopping, alternating activities and abstraction falls into a pattern of behavioral inactivation and inhibition. The salience network normally functions to switch between default mode and executive function such that internal preoccupation does not preclude the execution of stimulating, rewarding activities.
- Schmaal L
- van Harmelen A-L
- Chatzi V
- et al.
Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies.
Mol Psychiatry. 2020; 25: 408-427
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Published online: May 07, 2020
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