There is a growing consensus on the influence neural networks of the mesocorticolimbic
brain system on neuropsychiatric disorders. Neural networks consist of clusters of
connected circuits identified with functional magnetic resonance imaging of the brain.
Multiple networks including the default mode network (DMN), salience network, and
executive function also described as the cognitive control network are implicated
in both the presentation of depressive symptoms but also as moderators of treatment
response. Aberrations in the functional connectivity patterns both within and between
these networks are implicated in mood disorders and suicidality.
1
The DMN sometimes said to be the daydreaming or self-reflection network, becomes
overly engaged with internally preoccupied thought during depressive episodes. The
executive function network which normally is involved in planning, initiating, stopping,
alternating activities and abstraction falls into a pattern of behavioral inactivation
and inhibition. The salience network normally functions to switch between default
mode and executive function such that internal preoccupation does not preclude the
execution of stimulating, rewarding activities.To read this article in full you will need to make a payment
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Article info
Publication history
Published online: May 07, 2020
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© 2020 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.
