Metabolic Syndrome: A Matter of The Heart and the Brain

  • Neha Jain
    Send correspondence and reprint requests to Neha Jain, M.D., FAPA, Department of Psychiatry, University of Connecticut Health Center, 263 Farmington Ave., Farmington, CT 06030.
    Department of Psychiatry, University of Connecticut Health Center, Farmington, CT
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Published:February 21, 2019DOI:
      Over the past decade, there has been increasing interest clinically and scientifically in the effect of the Metabolic Syndrome (MetS) —a cluster of factors including abdominal obesity, hypertriglyceridemia, low high-density lipoprotein, hypertension, and hyperglycemia—on brain function and cognitive impairment. MetS is an emerging epidemic, with overall prevalence rates of 33% in the United States, with higher rates among women than men, and among Hispanics compared with other racial groups.
      • Aguilar M
      • Bhuket T
      • Torres S
      • et al.
      Prevalence of the metabolic syndrome in the United States, 2003-2012.
      The prevalence of MetS increases with age, with more than 50% of women and people of Hispanic ethnicity over the age of 60 presenting with risk conditions.
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        • Aguilar M
        • Bhuket T
        • Torres S
        • et al.
        Prevalence of the metabolic syndrome in the United States, 2003-2012.
        JAMA. 2015; 313: 1973-1974
        • Atti AR
        • Valente S
        • Iodice A
        • et al.
        Metabolic syndrome (MetS), mild cognitive impairment (MCI) and dementia: a meta-analysis of longitudinal studies [Epub ahead of print].
        Am J Geriatr Psychiatry. 2019 Feb 15;
        • Hao Z
        • Wu B
        • Wang D
        • et al.
        Association between metabolic syndrome and cognitive decline: a systematic review of prospective population-based studies.
        Acta Neuropsychiatr. 2011; 23: 69-74
        • Profenno LA
        • Porsteinsson AP
        • Faraone SV
        Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders.
        Biol Psychiatry. 2010; 67: 505-512
        • Moorhouse P
        • Rockwood K
        Vascular cognitive impairment: current concepts and clinical developments.
        Lancet Neurol. 2008; 7: 246-255
        • Sutton EF
        • Beyl R
        • Early KS
        • et al.
        Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes.
        Cell Metab. 2018; 27: 1212-1221
        • Nassis GP
        • Papantakou K
        • Skenderi K
        • et al.
        Aerobic exercise training improves insulin sensitivity without changes in body weight, body fat, adiponectin, and inflammatory markers in overweight and obese girls.
        Metabolism. 2005; 54: 1472-1479