Introduction: The frequency of adverse drug reactions (ADRs) and therapeutic failures are often
increased in elderly patients. Individual genetic variations in drug-metabolizing
enzymes and neurotransmitter transporters and receptors add to the heterogeneity of
treatment response and safety. Selection of genetically concordant medications is
not only important for proper efficacy and avoiding ADRs, but also affects polypharmacy,
the number of prescriptions needed to treat psychiatric and associated comorbid conditions,
and therefore also impacts healthcare costs.
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