Abstract| Volume 25, ISSUE 3, SUPPLEMENT , S143-S144, March 2017

Combinatorial Pharmacogenomics Reduces Polypharmacy and Medication Cost in Elderly Patients with Anxiety and Depression

      Introduction: The frequency of adverse drug reactions (ADRs) and therapeutic failures are often increased in elderly patients. Individual genetic variations in drug-metabolizing enzymes and neurotransmitter transporters and receptors add to the heterogeneity of treatment response and safety. Selection of genetically concordant medications is not only important for proper efficacy and avoiding ADRs, but also affects polypharmacy, the number of prescriptions needed to treat psychiatric and associated comorbid conditions, and therefore also impacts healthcare costs.
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